Work Package 1 – Core Outcome Set

Thanks!

Huge thanks to all involved from the following hospital sites:

• Salford Royal NHSFT
• Wrightington, Wigan and Leigh Teaching Hospitals NHSFT
• Royal Devon & Exeter Hospital NHSFT
• Cambridge University Hospital
• Newcastle upon Tyne Hospitals NHSFT
• University Hospital Southampton NHSFT
• The Queen Elizabeth Hospital Kings Lynn NHSFT
• Norfolk & Norwich University Hospitals NHSFT
• Royal Cornwall Hospitals NHS Trust
• Liverpool University Hospitals NHSFT
• Hull University Teaching Hospitals NHS Trust
• Fairfield General Hospital, Pennine Acute NHS Hospitals NHS Trust, part of Northern Care Alliance
• Harrogate & District NHSFT
• University Hospitals of Coventry and Warwickshire NHS Trust
• Northumbria Healthcare NHSFT

Overview

Developing a Core Outcome Set for hospital deprescribing trials

In order to test whether the CHARMER deprescribing intervention is effective, we need to know what outcomes are the most important for us to measure. We have developed a Core Outcome Set for hospital deprescribing trials, which is a minimum set of outcomes that should be measured in all studies testing whether a hospital deprescribing intervention is effective. This will help researchers and policy makers to easily compare different hospital deprescribing interventions because they will all have been tested using the same outcomes.

We developed the Core Outcome Set collaboratively with our 200 stakeholders of older people and informal carers, healthcare professionals, hospital managers and researchers from around the world. We started with 113 potentially important outcomes and our stakeholders chose the following six to include in the final Core Outcome Set:

We will collect the six core outcomes in Work Package 3 (feasibility study) and Work Package 4 (definitive trial) to test the CHARMER intervention. The Core Outcome Set will also provide an agreed standardised set of outcomes that should be measured and reported in all subsequent hospital deprescribing trials.

You can find out more about the Core Outcome Set and how it was developed in our Plain English Summary, our research article published in Age and Ageing and by watching the video below:

Patient and public involvement members advised on the design and content of materials for practitioner participants and worked collaboratively with work package leads to develop the patient/carer study materials. They also supported preparation with research assistants to undertake telephone interviews with stakeholders and were integral members of the research team when analysing the results of the study.

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Work Package Team

If you have any questions about Work Package 1, please contact Dr Jackie Martin-Kerry.